House Season 1 Episode 7 : Fidelity

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Fidelity

Two men are out jogging – one of them (guest star Dominic Purcell) returns home to his bedridden wife, who lashes out at him. Believing there is something wrong, she is sent to Princeton-Plainsboro, and when all the treatments fail, House concludes she has African sleeping sickness. However, neither the wife nor her husband have ever been to Africa. The woman will die without proper treatment, but neither one will also admit to having an affair.